For individuals struggling with treatment-resistant depression, Spravato (esketamine) offers a promising new path when traditional antidepressants have fallen short. Unlike standard medications that can take weeks to show results, Spravato may begin working more quickly, sometimes within hours or days, depending on the individual.

Spravato is a nasal spray administered under clinical supervision and typically prescribed alongside an oral antidepressant. Most treatment plans start with twice-weekly sessions for the first four weeks, followed by a gradual reduction in frequency. Patients often report feeling subtle emotional shifts within the first two to three treatments. While some experience rapid improvement, for others, it may take a few weeks to notice significant changes in mood, motivation, or energy levels.

The medication works differently from traditional antidepressants by targeting the brain’s glutamate system. This alternative mechanism allows Spravato to deliver faster symptom relief, particularly for individuals who have not responded well to selective serotonin reuptake inhibitors (SSRIs) or other common medications. However, results vary depending on factors such as overall health, coexisting conditions, and adherence to the treatment schedule.

It’s essential to attend all recommended sessions, as the full benefits of Spravato are typically realized over time. Patients are closely monitored during and after each administration to ensure safety and to track progress. While some may see improvement early on, consistent follow-up helps determine the treatment’s long-term effectiveness.

Spravato treatment is offered at Kema Health Services under the care of licensed professionals who provide safe, personalized support throughout the process. To find out if Spravato could be right for you, we invite you to speak with our clinical team directly and explore your options for advanced depression care.